Use of Platelet-rich Plasma in an Experimental Rheumatoid Arthritis Model

Posted in: General | Posted on: 14-Nov-2016

separated into: Control Group 7 (CG7) and 21 (CG21) days; Experimental Group 7 (EG7) and 21 (EG21) days. RA was induced through intraarticular knee with 100 μL Freud\'s complete adjuvant. On day 10, in GE7 and 21 were injected 100 μL PRP while those in GC7 and CG21 were injected 100 μL phosphate-buffered saline (PBS). On day 8 animals in EG7 and CG7 groups were euthanized. A second injection of 100 μL PRP and 100 μL PBS were performed on day 8 in EG21 and CG21, respectively. As result, we observed that granulation and necrosis tissue were intensely formed in CG7 while in EG7 was lightly formed with moderate osteogenesis and neovascularization. CG21 still presented moderate necrosis tissue, polymorphonuclear cells, and moderate emergence of capillaries, while EG21 showed decreased intensity of capillaries with low granulation tissue. EG21 showed bone tissue cells at a moderate level and subchondral bone formation. In conclusion, PRP intra-articular can be used as a co-adjuvant RA treatment because it was effective in controlling osteogenesis and stimulating the deposit of collagen fibers in cartilage