Efficacy of Autologous Bone Marrow Concentrate for Knee Osteoarthritis with and without Adipose Graft

Knee osteoarthritis (OA) is a significant health problem with increasing impact on public health [1]. In 2009 there were approximately 600,000 total knee arthroplasties (TKAs)\nperformed for knee OA, more than double the number performed 10 years earlier [2]. Total or partial joint arthroplasty surgeries are highly invasive procedures, requiring\nsurgical resection of all or parts of the joint and insertion of a prosthesis [3]. Complications can be significant and include death, pulmonary embolism, stroke, and myocardial\ninfarction [4-7]. While many patients who undergo TKA experience improved function and decreased symptoms, many others continue to have some degree of ongoing pain. A recent investigation of post-TKA symptoms reported chronic pain in 88% of patients who have had the surgery [8].