Blog

Platelet Rich Plasma Injection Used as Treatment of High- Grade Partial Pectoralis Muscle Tear in Division I Football Player
Posted in: General | Posted on: 15-Jan-2018
Abstract
This case report describes a collegiate football player diagnosed with a high-grade partial pectoralis major tear, patient outcome after non-operative management using platelet-rich plasma injections, and a detailed description of the rehabilitation program used in this case. The purpose of this article is to describe a newer option for the management of this injury and give context to clinical decision-making in this setting.
Read more
Comparative effectiveness of intra-articular prolotherapy versus peri-articular prolotherapy on pain reduction and improving function in patients with knee osteoarthritis: A randomized clinical trial.
Posted in: General | Posted on: 07-Jan-2018
Abstract
Background: Osteoarthritis is a common degenerative disease. Prolotherapy is an alternative therapy used in multiple musculoskeletal disorders. Objective: To compare the effectiveness of intra-articular dextrose injection versus peri-articular prolotherapy in patients with knee osteoarthritis (KOA). Methods: Fifty-two adults with painful primary knee osteoarthritis for at least three months were randomized to intra- and peri-articular injection groups. Prolotherapy was done twice with two week intervals. The outcome measures included the Oxford Knee Scale (OKS), Western Ontario McMaster University Osteoarthritis Index (WOMAC), and Visual Analogue Scale (VAS), which were obtained from patients before the first injection at the base line and after the second injection at the fourth and eighth weeks. Results: There were no statistically significant differences between demographic characteristics; before the injection, pain intensity, OKS, and WOMAC scores were approximately equal between the two groups. After dextrose prolotherapy, VAS, OKS, and WOMAC scores improved from baseline through the fourth and eighth weeks in both groups without any superiority between the two methods of injections (p<0.001). Conclusion: Dextrose prolotherapy either intra- or peri-articular injection resulted in significant improvement, so it could be an inexpensive and effective management of knee osteoarthritis.
\n
Read more
Platelet-rich plasma inhibits Wnt/β-catenin signaling in rabbit cartilage cells activated by IL-1β
Posted in: General | Posted on: 02-Jan-2018
Abstract
Objective: Platelet-rich plasma (PRP) has been reported to alleviate degenerative pathological damage to joint cartilage. This study aimed to investigate the effect of PRP on Wnt/β-catenin signaling in rabbit chondrocytes.
Methods: Using 3-month-old New Zealand white rabbits, PRP was prepared from venous blood, and chondrocytes were cultured from knee joint cartilage and identified by staining for type II collagen and proteoglycan. The effects of PRP on chondrocyte viability were measured. The chondrocytes were divided into 5 groups: control, IL-1β, PRP (100-fold dilution), Dkk-1 (100 ng/mL) and Dkk-1 + PRP. The IL-1β, PRP, Dkk-1 and Dkk-1 + PRP groups were treated with interleukin (IL)-1β (50 μL, 10 μg/mL) for24 h. Chondrocyte morphology was observed by electron microscopy. Levels of carboxy terminal peptide (CTX-II) and cartilage oligomeric matrix protein (COMP) in culture media were measured by ELISA. Wnt-1, β-catenin and GSK-3β mRNA and protein expression were determined by RT-PCR and western blot respectively.
\n
Read more
Platelet-rich plasma has beneficial effects in mice with osteonecrosis of the femoral head by promoting angiogenesis
Posted in: General | Posted on: 01-Jan-2018
Abstract
Platelet-rich plasma (PRP) is autologous and multifunctional. Platelet concentrate from blood contains highly concentrated platelets and various types of cells, including growth factors. PRP promotes the recovery of cell proliferation and differentiation. Osteonecrosis of the femoral head is a disease caused by femoral head damage or an insufficient blood supply, which leads to the death of bone cells and abnormal bone marrow composition. The subsequent repair of bone cells may result in changes to the structure of femoral head, femoral head collapse and joint dysfunction. PRP may promote the repair of injured articular cartilage in patients with joint diseases through the removal of harmful inflammatory factors. In the present study, the therapeutic effects and primary mechanism of PRP action were investigated using a glucocorticoid-induced femoral head osteonecrosis mouse model.
Read more
Freeze-Dried Chitosan-PRP Injectable Surgical Implants for Meniscus Repair: Pilot Feasibility Studies in Ovine Models
Posted in: General | Posted on: 01-Jan-2018
Abstract
Clinical management of meniscus tears often involves partial meniscectomy, which can lead to Osteoarthritis (OA). Meniscus repair augmentation strategies are being developed to compensate for the tissue\'s limited healing response. The purpose of the study was to assess the feasibility of using implants composed of freeze-dried Chitosan (CS) solubilized in Platelet-Rich Plasma (PRP) to improve meniscus repair in ovine models. Lyophilized formulations containing 1% (w/v) chitosan (degree of deacetylation 82% and number average molar mass 38 kDa), 1% (w/v) trehalose and 42.2 mM calcium chloride were solubilized in autologous PRP and applied to surgically induced meniscus lacerations.
Read more
Treating de querveins tensynovitis using the prp technique : a case series
Posted in: General | Posted on: 01-Jan-2018
Abstract
PRP is the acronym for platelet rich plasma, an autologous, biological blood derived product which is exogenously applied to tissue areas where regeneration or healing is desired. Together with the platelets, high concentration of essential growth factors is harvested, and these includes platelet-derived growth factors (PDGF), vascular endothelial growth factors (VEGF), interleukin-like factors (IGF), fibronectin to name but a few , which is thought to enhance repair. First described in 1987 with success in an open heart surgery in Italy, PRP has found its fame and is now widely used in many areas of specialty, including sports medicine for treatment of musculoskeletal injuries, orthopedics for enhancement of bone healing, osteoarthritis, aesthetics medicine where ladies and men alike inject PRP onto their faces to increase radiance and reduce wrinkles, and as recent as 2013 in the field of urology to treat organic erectile dysfunction. The potential of PRP treatment is limitless, with many upcoming large scale studies backing its success. Principles of its application include obtaining a platelet concentrate 3-5 times its normal physiological levels and injecting it into areas where healing is desired.
Read more
Ultrasound-Guided Platelet-Rich Plasma Injection in a Patient with a Plantar Fascia Tear
Posted in: General | Posted on: 25-Dec-2017
Abstract
Department of Physical Medicine and Rehabilitation, Ankara Physical Medicine and Rehabilitation Training and Research Hospital, Ankara, Turkey.
Read more
Injectable-platelet rich fibrin using the low speed centrifugation concept improves cartilage regeneration when compared to platelet-rich plasma
Posted in: General | Posted on: 19-Dec-2017
Abstract
The aim of the present study was to evaluate the effect of injectable platelet-rich fibrin (i-PRF) on cultivated chondrocytes and osteochondral regeneration in critical-sized osteochondral defect of the rabbit\'s knee in comparison to autologous platelet-rich plasma (PRP). Chondrocytes were first investigated for their ability to proliferate and differentiate in response to PRP and i-PRF. Thereafter, full-thickness critical-sized osteochondral defects 5 mm in diameter and 5 mm in depth were created in the knee joint of 12 adult female New Zealand White rabbits. Defects were regenerated with either PRP or i-PRF and compared to control. Animals were sacrificed at 4 and 12 weeks postoperatively and evaluated histologically by macroscopic and microscopic examination for cartilage regeneration. i-PRF significantly promoted chondrocyte proliferation and mRNA levels of Sox9, collagen type II, and aggrecan when compared to PRP and control.
\n
Read more
Happy holidays from Dr Weglein Office
Posted in: General | Posted on: 18-Dec-2017
Happy holidays from Dr Weglein Office
Read more
Men and Women Differ in the Biochemical Composition of Platelet-Rich Plasma
Posted in: General | Posted on: 12-Dec-2017
Abstract
Background: Autologous platelet-rich plasma (PRP) is widely used for a variety of clinical applications. However, clinical outcome studies have not consistently shown positive effects. The composition of PRP differs based on many factors. An improved understanding of factors influencing the composition of PRP is important for the optimization of PRP use.
Conclusion: This study in healthy patients shows differences in the composition of PRP between men and women, with sex being a greater factor than age. There was also proteomic variability within the groups. These data support a personalized approach to PRP treatment and highlight the need for a greater understanding of the relationships between proteomic factors in PRP and clinical outcomes.
Read more
Efficacy Of Platelet Rich Plasma Versus Teroid Injection In Planter Fasciitis
Posted in: General | Posted on: 30-Nov-2017
Abstract
Background: Plantar fasciitis is local inflammation and fibrosis of the plantar aponeuroses reducing the quality of life and productivity of affected individuals. Pain in the heel and bottom of the foot is the ultimate outcome
Objectives: To compare the effect of platelet rich plasma and steroid injections among patients having planter fasciitis.
Read more
Role of leukocyte free platelet rich plasma in planter fasciitis: a prospective study
Posted in: General | Posted on: 30-Nov-2017
Abstract
Background: Planter fasciitis, is by definition, inflammation of planter fascia. Most of the cases are well treated conservatively and a few responds to surgery only. Objectives of present study were evaluating the efficacy of a single injection of leukocyte free platelet rich plasma in plantar fasciitis and to derive a correlation between the clinical and radiological outcome.
Methods: The present study consisted of 120 patients of bilateral (PF), (240 feet). These patients were divided into two groups PRP group of 60 patients and Placebo group of 60 patients. The study was conducted on patients attending Orthopaedics outpatient department Post Graduate Institute of Medial Education and Research (PGIMER) from July 2011 to June 2012. A primary efficacy criterion was changes from baseline in pain using (VAS). Functional results, level of satisfaction and outcome were measured by - AOFAS Foot Scale. Correlation of clinical with radiological outcome were performed.
Read more
The use of lumbar epidural injection of platelet lysate for treatment of radicular pain
Posted in: General | Posted on: 30-Nov-2017
Abstract
Background: Epidural steroid injections (ESI) are the most common pain management procedure performed in the US, however evidence of efficacy is limited. In addition, there is early evidence that the high dose of corticosteroids used can have systemic side effects. We describe the results of a case series evaluating the use of platelet lysate (PL) epidural injections for the treatment of lumbar radicular pain as an alternative to corticosteroids.
Methods: Registry data was obtained for patients (N = 470) treated with PL epidural injections presenting with symptoms of lumbar radicular pain and MRI findings that were consistent with symptoms. Collected outcomes included numeric pain score (NPS), functional rating index (FRI), and a modified single assessment numeric evaluation (SANE) rating.
Read more
Platelet Rich Plasma Supports Proliferation and Re-differentiation of Chondrocytes during In Vitro Expansion
Posted in: General | Posted on: 28-Nov-2017
Abstract
Articular cartilage regeneration is insufficient to restore sports injuries or defects that can occur from trauma. Treatment options for cartilage repair include autologous chondrocyte implantation (ACI) by isolation, expansion, and reimplantation of healthy donor chondrocytes. Chondrocyte expansion onto 2D substrates leads to dedifferentiation and loss of the cellular phenotype. We aimed to overcome the state of dedifferentiation by biochemical stimuli with platelet derivatives such as platelet rich plasma (PRP) and hyper acute serum (HAS) to achieve sufficient cell numbers in combination with variable oxygen tension. Human articular chondrocytes from osteoarthritic (OA) cartilage chondrocytes were switched from 10% FCS supplementation to either 10% PRP or 10% HAS after initial passaging for further experiments under normoxic (20%O2) or hypoxic (1%O2) conditions.
Read more
Dr Weglein with Dr Stan lam in Hong Kong
Posted in: General | Posted on: 27-Nov-2017
Dr Weglein with Dr Stan lam in Hong Kong
Read more
Platelet-rich plasma versus hyaluronic acid to treat tendinopathies
Posted in: General | Posted on: 26-Nov-2017
Abstract
Introduction: The treatment of patellar tendinopathies could be difficult. This is the reason why new treatments have been developed, among which platelet rich plasma (PRP) injections. Some clinical series have previously evaluated the effect of PRP in the treatment of proximal patellar tendinopathies. Recent systematic review concluded that PRP could be recommend as a treatment in such indication (1). Recently, the viscoelastic properties of hyaluronic acid (HA) on liquid connective tissue have been proposed for the treatment of tendinopathies (2). Some fundamental studies show encouraging results on HA\'s ability to promote tendon gliding and reduce adhesion as well as to improve tendon architectural organisation. Some observations also support its use in a clinical setting to improve pain and function.
\n
Purpose: We aimed to compare the effect of PRP injection versus two injections of HA after three months on patients who have a proximal patellar tendinopathy.
Read more
Efficacy of platelet-rich plasma injections for symptomatic tendinopathy: systematic review and meta-analysis of randomised injection-controlled trials
Posted in: General | Posted on: 12-Nov-2017
Abstract
Aim To determine the efficacy of platelet-rich plasma (PRP) injections for symptomatic tendinopathy.
Results: A total of 16 randomised controlled trials (18 groups) of PRP versus control were included. Median sample size was 35 patients, a study size that would require an effect size ≥1.0 to achieve statistical significance. PRP was more efficacious than control in reducing tendinopathy pain, with an effect size of 0.47 (95% CI 0.22 to 0.72, p<0.001), signifying a moderate treatment effect. Heterogeneity among studies was moderate (I2=67%, p<0.001). In subgroup analysis and meta-regression, studies with a higher proportion of female patients were associated with greater treatment benefits with PRP.
Conclusions: Injection of PRP is more efficacious than control injections in patients with symptomatic tendinopathy.
Read more
Hydrodissection of an Achilles Tendinopathy on a Professional Athlete
Posted in: General | Posted on: 09-Nov-2017
Abstract
We report a case of Achilles tendinosis that was treated with a high volume, hydrodissection visualized by conventional B-mode ultrasound. Prior MRI revealed a thickened right Achilles tendon with a small defect. Ultrasound examination showed a thickened Achilles tendon with physical exam revealing a prominent Haglund\'s deformity, mild fusiform swelling and pain along the posterior Achilles (Figure 1 & 2). The condition had been poorly responsive to standard management including protected ambulation in a cam walker boot, anti-inflammatory medication, modalities and therapeutic exercise, as well as a platelet rich plasma injection. We suggest using high volume ultrasound guided injection adjacent to (anterior to) the Achilles tendon as an adjunct to treat this difficult clinical syndrome.
Read more
Platelet rich plasma - A new revolution in medicine
Posted in: General | Posted on: 01-Nov-2017
Abstract
In the recent years there has been a paradigm shift in consideration of platelets from being just hemostatic cells to actually performing a myrad of diverse functions. The recent use of Platelet Rich Plasma as therapeutic agent is based on its growth factor content and the matrix provided by the platelets themselves. An overview of PRP, its uses in the field of medicine is provided for correct understanding of PRP therapy. Standardization of preparation and administration also remains a challenge due to various variables present. How beneficial are these individually tailored protocols, still remains to be seen.
Blood is mainly liquid plasma containing small solid components such as RBC, WBC and platelets. Platelets contain different growth factors and cytokines contributing to haemostasis and capable of stimulating healing of both bone and soft tissue.
\n
Read more
Platelet-rich plasma: combinational treatment modalities for musculoskeletal conditions
Posted in: General | Posted on: 26-Oct-2017
Abstract
Current research on common musculoskeletal problems, including osteoarticular conditions, tendinopathies, and muscle injuries, focuses on regenerative translational medicine. Platelet-rich plasma therapies have emerged as a potential approach to enhance tissue repair and regeneration. Platelet-rich plasma application aims to provide supraphysiological concentrations of platelets and optionally leukocytes at injured/pathological tissues mimicking the initial stages of healing. However, the efficacy of platelet-rich plasma is controversial in chronic diseases because patients\' outcomes show partial improvements. Platelet-rich plasma can be customized to specific conditions by selecting the most appropriate formulation and timing for application or by combining platelet-rich plasma with synergistic or complementary treatments. To achieve this goal, researchers should identify and enhance the main mechanisms of healing. In this review, the interactions between platelet-rich plasma and healing mechanisms were addressed and research opportunities for customized treatment modalities were outlined. The development of combinational platelet-rich plasma treatments that can be used safely and effectively to manipulate healing mechanisms would be valuable and would provide insights into the processes involved in physiological healing and pathological failure.
\n\n
Read more

First | Previous | Pages 1 2 3 4 [5] 6 7 8 9 10 of 31 | Next | Last