Blog

• Treatment of lateral epicondylitis with autologous platelet rich plasma injection

  Posted on: 30-Sep-2018

  Abstract

  Outcomes of traditional treatment methods of lateral epicondylitis are variable because of poor tendon healing properties secondary to poor vascularization. Platelet rich plasma provides locally high concentration of growth factors and have shown its efficacy in many tendinopathies and wound healing. We tried to measure the efficacy of locally injected autologous PRP, subjectively by functional oxford elbow score and pain score as well as objectively by ultrasonographic evaluation of the morphologic changes (focal hypoechoic, odema, tendon thickness, fraying, tear, cortical erosion, calcification) in common extensor origin in 30 patients with mean age of 39.3 years of recalcitrant lateral epicondylitis.

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• Clinical and radiographic comparison of a single LP-PRP injection, a single hyaluronic acid injection and daily NSAID administration with a 52-week follow-up: a randomized controlled trial

  Posted on: 27-Aug-2018

  Abstract

  Background Knee osteoarthritis (OA) is a disease with a high prevalence in the adult population. Nonsteroidal anti-inflammatory drugs (NSAID) or intra-articular injections [hyaluronic acid (HA) or platelet-rich plasma (PRP)] can provide clinical benefit. Magnetic resonance imaging (MRI) has proven to be useful for the evaluation of cartilage volume and thickness in knee osteoarthritis. The purpose of this study was to evaluate the benefit provided by PRP injection in comparison with hyaluronic acid and NSAID in knee OA patients and to compare the radiographic evolution at the 52-week follow-up.

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• The use of Platelet Rich Plasma in the Management of Plantar Fasciitis: A Systematic Review

  Posted on: 13-Aug-2018

  Introduction

  Plantar fasciitis (PF) is the most common cause of heel pain. Approximately 10% of the population develops the condition throughout life. The main symptoms are morning pain and pain at the beginning of activities (after resting time). Pain is felt near the medial and proximal insertion of the plantar fascia in the calcaneus tuberosity, or, less commonly, under heel pad, which leads to dysfunction and limitation for recreational and work activities (Zhiyun et al., 2013; Riddle et al., 2003).

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• Comparative Effect Of Dextrose Prolotherapy And Platelet Rich Plasma Therapy In Primary Osteoarthritis Knee

  Posted on: 08-Aug-2018

  Introduction

  Primary Osteoarthritis knee most common degenerative condition in old age group. Osteoarthritis knee produce greater impact on physical activity and quality of life. Objective & Aim: Evaluate and Compare the effect of Dextrose prolotherapy and Platelet rich plasma therapy on Functional & Clinical outcome.

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• Platelet-rich plasma and corticosteroid injection in lateral epicondylitis: Who is great

  Posted in: Stem Cell Treatment Houston | Posted on: 18-Jul-2018

  Introduction/Background

  Elbow epicondylar tendinitis is a common problem that usually resolves with nonoperative treatments. When these measures fail, there is a role of Platelet-rich plasma (PRP) for tissue repair.

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• Volumetric findings of MRI after platelet rich plasma injection in knee osteoarthritis (A randomized clinical trial)

  Posted in: Stem Cell Treatment Houston | Posted on: 18-Jul-2018

  Introduction/Background

  
  
  

  Most of studies have focused on subjective and clinical symptoms effect of PRP and fewer papers have studied its objective effect on cartilage. In this study, we investigated the effect of PRP on cartilage characteristics by special MRI sequencings.

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• Ultrasound-guided injection of platelet rich plasma versus corticosteroid for treatment of rotator cuff tendinopathy: Effect on shoulder pain, disability, range of motion and ultrasonographic findings

  Posted in: General | Posted on: 09-Jul-2018

  Abstract

  
  

  To compare the efficacy of ultrasound-guided platelet rich plasma (PRP) versus corticosteroid injection for treatment of rotator cuff tendinopathy (RCT).

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• Platelet-Rich Plasma, Hydroxyapatite and Chitosan in the Bone and Cartilaginous Regeneration of Femoral Trochlea in Rabbits: Clinical, Radiographic and Histomorphometric Evaluations

  Posted on: 03-Jul-2018

  Cartilaginous tissue is mainly present in the joints, and it consists predominantly of type II collagen and glycoproteins, which promote the tissue functions of supporting biomechanical forces, such as tension and compression, generated during the process of ambulation. The articular cartilage has a very limited regenerating or healing capacity in lesions with no involvement of the subchondral bone, resulting in an empty lacuna. This characteristic of the tissue causes traumas or degenerative diseases in this region, which are difficult to solve.

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• AB0975 Does platelet rich plasma change the volumetric findings of mri imaging? (A Randomised Clinical Trial)

  Posted in: General | Posted on: 20-Jun-2018

  Abstract

  Background Several studies have shown the effect of platelet rich plasma (PRP) on knee osteoarthritis. Most of these studies have focused on subjective and clinical symptoms effect of PRP and fewer papers have studied its objective effect on cartilage. MRI is the gold standard imaging for cartilage lesion.

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• Rehabilitation of hamstring strains: does a single injection of platelet-rich plasma improve outcomes? (Clinical study)

  Posted in: General | Posted on: 18-Jun-2018

  Purpose: The study aims to elucidate the effects of single platelet-rich plasma (PRP) injection combined with rehabilitation exercises on growth factor concentrations and muscle strength following hamstring tear injury.

  Methods: 17 physically active male athletes (22.3 years; 1.80 m; 74.7 kg; 24.9 kg/m2) with a 2nd-grade acute hamstring tear were randomized to a treatment group (n = 8) or control group (n = 9). Both groups received the same physical rehabilitation program for 8 weeks; however, only the treatment group received an autologous single PRP injection.

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• Platelet-rich plasma therapy in refractory knee osteoarthritis combined with infection

  Posted in: General | Posted on: 05-Jun-2018

  Abstract: Objective: To clarify the clinical efficacy of platelet-rich plasma (PRP) in the treatment of patients with refractory knee osteoarthritis (KOA) combined with infection. Methods: Between June 2014 and June 2016, 60 refractory KOA patients with infection (non-pyogenic infection) admitted to Ningbo NO.6 Hospital were recruited in this study. The patients were randomly assigned to receive either PRP plus antibiotics (A group, n=30) or sodium hyaluronate and antibiotics (B group, n=30).

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• Evaluating the Efficacy of Different Platelet-Rich Plasma Regimens for Management of Androgenetic Alopecia: A Single-Center, Blinded, Randomized Clinical Trial

  Posted in: General | Posted on: 05-Jun-2018

  BACKGROUND Studies suggest platelet-rich plasma (PRP) may mitigate androgenetic alopecia (AGA), but each varies in the frequency of and interval between treatments.

  OBJECTIVE To compare the efficacy, satisfaction, tolerability, and safety of 2 initial PRP injection protocols over 6 months.

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• Stem Cells for the Treatment of Knee Osteoarthritis: A Comprehensive Review

  Posted in: Stem Cell Treatment Houston | Posted on: 04-Jun-2018

  Background: Knee osteoarthritis (KOA) is a very challenging condition to treat and can be resistant to medications, procedures, and even surgery. Surgery may not be an option for some patients due to obesity or comorbidities. Regenerative medicine utilizing stem cells, platelet rich plasma (PRP), amniotic fluid, and cytokine modulation is very promising in the treatment of KOA.

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• Stem Cell Therapies for Neurodegenerative Diseases

  Posted in: Stem Cell Treatment Houston | Posted on: 13-May-2018

  Stem cell therapies have been proposed as a treatment option for neurodegenerative diseases, but the best stem cell source and therapeutic efficacy for neuroregeneration remain uncertain. Embryonic stem cells (ESCs) and neural stem cells (NSCs), which can efficiently generate neural cells, could be good candidates but they pose ethical and practical issues. Not only difficult to find the good source of those cells but also they alway pose immunorejection problem since they may not be an autologous cells.

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• Treating Age-Related Diseases with Somatic Stem Cells

  Posted in: Stem Cell Treatment Houston | Posted on: 13-May-2018

  Life expectancy in the developed world has advanced beyond the number of years in which healthy tissue homeostasis can be maintained, and as a result, the number of persons with severe and debilitating chronic illnesses, including cancer, diabetes, osteoarthritis, osteoporosis, neurodegenerative and cardiovascular disease has continued to rise. One of the key underlying causes for the loss in the ability to replenish damaged tissues is the qualitative and quantitative decline in somatic stem cell populations.

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• Stem Cell Therapy for Osteonecrosis of the Femoral Head: Current Trends and Comprehensive Review

  Posted in: Stem Cell Treatment Houston | Posted on: 09-May-2018

  Abstract

  Purpose of Review

  Osteonecrosis of the femoral head (ONFH) is a common and frequently occurring disease. It is caused by interruption of blood supply with different etiologies. ONFH leads to degeneration and necrosis of the subchondral bone of the femoral head and eventually collapse of the femoral head. ONFH has a high disability rate, seriously affecting the quality of living of patients, and often involves middle-aged and younger people.

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• A Comprehensive Review of Stem Cells for Cartilage Regeneration in Osteoarthritis

  Posted in: Stem Cell Treatment Houston | Posted on: 09-May-2018

  Osteoarthritis (OA) is an age related joint disease associated with degeneration and loss of articular cartilage. Consequently, OA patients suffer from chronic joint pain and disability. Weight bearing joints and joints that undergo repetitive stress and excessive ‘wear and tear’ are particularly prone to developing OA. Cartilage has a poor regenerative capacity and current pharmacological agents only provide symptomatic pain relief.

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• Peripheral Blood Mononuclear Cells Enhance Cartilage Repair in in vivo Osteochondral Defect Model

  Posted in: General | Posted on: 07-May-2018

  Abstract

  This study characterized peripheral blood mononuclear cells (PBMC) in terms of their potential in cartilage repair and investigated their ability to improve the healing in a pre-clinical large animal model. Human PBMCs were isolated with gradient centrifugation and adherent PBMC’s were evaluated for their ability to differentiate into adipogenic, chondrogenic and osteogenic lineages and also for their expression of musculoskeletal genes. The phenotype of the PBMCs was evaluated using Stro-1, CD34, CD44, CD45, CD90, CD106, CD105, CD146 and CD166 cell surface markers. Osteochondral defects were created in the medial femoral condyle (MFC) of 24 Welsh mountain sheep and evaluated at a six month time point. Four cell treatment groups were evaluated in combination with collagen-GAG-scaffold: (1) MSC alone; (2) MSCs and PBMCs at a ratio of 20:1; (3) MSCs and PBMC at a ratio of 2:1 and (4) PBMCs alone. Samples from the surgical site were evaluated for mechanical properties, ICRS score and histological repair.

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• A Review of Mesenchymal Stem Cell Injections for Osteoarthritis

  Posted in: General | Posted on: 07-May-2018

  Abstract

  Mesenchymal stem cell (MSC) injections for osteoarthritis is reviewed

  Methods: PubMed search was conducted to identify articles in English from 2003-2018 that used intraarticular injection (IA), cartilage repair, cartilage regeneration, chondral injury, adipose stem cells, bone marrow stem cells, mesenchymal stem cells, or autologous stem cells.

  Osteoarthritis (OA) is a degenerative disease of diarthrodial joints characterized by loss of articular cartilage, deformity, and pain. The two greatest risk factors for OA are obesity and joint injury. Symptomatic OA is reported in 12% of American adults, with as many as 37% of adults demonstrating radiographic evidence of OA.

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• Comparison of the Regenerative Effects of Platelet Rich Fibrin and Plasma Rich in Growth Factors on Injured Peripheral Nerve: An Experimental Study

  Posted in: General | Posted on: 25-Apr-2018

  Abstract

  Purpose: The aim of the study was to investigate the effects of platelet rich fibrin (PRF) and plasma rich in growth factors (PRGF) on the injured peripheral nerve in the early period of healing.

  Results: Regarding electrophysiological evaluation, both the latency and amplitude values in D, PRF and PRGF groups were significantly lower than the C group (p> 0,05).

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